Journal:

Article Title: Pharmacodynamics of Telithromycin In Vitro against Respiratory Tract Pathogens

doi: 10.1128/AAC.45.1.23-29.2001

Figure Lengend Snippet: MICs of telithromycin, benzylpenicillin, and erythromycin for the investigated strains

Article Snippet: In the third set of experiments, S. pneumoniae ATCC 6306, S. pneumoniae 2151, S. pyogenes 138, S. pyogenes 197, H. influenzae CCUG 23969, and H. influenzae NTCC 8468 at three different inocula (approximately 10 4 , 10 6 , and 10 8 CFU/ml) were exposed to telithromycin at a concentration of four times the MIC for each strain.

Techniques:

Journal:

Article Title: Pharmacodynamics of Telithromycin In Vitro against Respiratory Tract Pathogens

doi: 10.1128/AAC.45.1.23-29.2001

Figure Lengend Snippet: (a) Killing curves for telithromycin at a concentration of 0.6 mg/liter against S. pneumoniae ATCC 6306 (□), S. pneumoniae 1020 (○), S. pneumoniae 2151 (▵). Control strains were S. pneumoniae ATCC 6306 (■), S. pneumoniae 1020 (●), and S. pneumoniae 2151 (▴). (b) S. pyogenes NTCC P1800 (□), S. pyogenes 197 (○), S. pyogenes 138 (▴). (c) H. influenzae NTCC 8468 (□), and H. influenzae CCUG 23969 (○). Controls strains were H. influenzae NTCC 8468 (■) and H. influenzae CCUG 23969 (●).

Article Snippet: In the third set of experiments, S. pneumoniae ATCC 6306, S. pneumoniae 2151, S. pyogenes 138, S. pyogenes 197, H. influenzae CCUG 23969, and H. influenzae NTCC 8468 at three different inocula (approximately 10 4 , 10 6 , and 10 8 CFU/ml) were exposed to telithromycin at a concentration of four times the MIC for each strain.

Techniques: Concentration Assay

Journal:

Article Title: Pharmacodynamics of Telithromycin In Vitro against Respiratory Tract Pathogens

doi: 10.1128/AAC.45.1.23-29.2001

Figure Lengend Snippet: Killing of gram-positive and gram-negative strains by telithromycin at a constant concentration of 0.6 mg/liter

Article Snippet: In the third set of experiments, S. pneumoniae ATCC 6306, S. pneumoniae 2151, S. pyogenes 138, S. pyogenes 197, H. influenzae CCUG 23969, and H. influenzae NTCC 8468 at three different inocula (approximately 10 4 , 10 6 , and 10 8 CFU/ml) were exposed to telithromycin at a concentration of four times the MIC for each strain.

Techniques: Concentration Assay

Journal:

Article Title: Pharmacodynamics of Telithromycin In Vitro against Respiratory Tract Pathogens

doi: 10.1128/AAC.45.1.23-29.2001

Figure Lengend Snippet: Killing of gram-positive and gram-negative strains by telithromycin at different concentrations

Article Snippet: In the third set of experiments, S. pneumoniae ATCC 6306, S. pneumoniae 2151, S. pyogenes 138, S. pyogenes 197, H. influenzae CCUG 23969, and H. influenzae NTCC 8468 at three different inocula (approximately 10 4 , 10 6 , and 10 8 CFU/ml) were exposed to telithromycin at a concentration of four times the MIC for each strain.

Techniques:

Journal:

Article Title: Pharmacodynamics of Telithromycin In Vitro against Respiratory Tract Pathogens

doi: 10.1128/AAC.45.1.23-29.2001

Figure Lengend Snippet: Killing curves for telithromycin against S. pneumoniae 2151 at starting inocula of approximately 104 CFU/ml (□), 106 CFU/ml (■), and 108 CFU/ml (┌) and against S. pyogenes 197 at starting inocula of approximately 104 CFU/ml (○), 106 CFU/ml (●), and 108 CFU/ml (⊕).

Article Snippet: In the third set of experiments, S. pneumoniae ATCC 6306, S. pneumoniae 2151, S. pyogenes 138, S. pyogenes 197, H. influenzae CCUG 23969, and H. influenzae NTCC 8468 at three different inocula (approximately 10 4 , 10 6 , and 10 8 CFU/ml) were exposed to telithromycin at a concentration of four times the MIC for each strain.

Techniques:

Journal:

Article Title: Pharmacodynamics of Telithromycin In Vitro against Respiratory Tract Pathogens

doi: 10.1128/AAC.45.1.23-29.2001

Figure Lengend Snippet: Killing of gram-positive and gram-negative strains at different inocula by telithromycin at four times the MIC

Article Snippet: In the third set of experiments, S. pneumoniae ATCC 6306, S. pneumoniae 2151, S. pyogenes 138, S. pyogenes 197, H. influenzae CCUG 23969, and H. influenzae NTCC 8468 at three different inocula (approximately 10 4 , 10 6 , and 10 8 CFU/ml) were exposed to telithromycin at a concentration of four times the MIC for each strain.

Techniques:

Journal:

Article Title: Pharmacodynamics of Telithromycin In Vitro against Respiratory Tract Pathogens

doi: 10.1128/AAC.45.1.23-29.2001

Figure Lengend Snippet: Pharmacokinetic-pharmacodynamic parameters obtained in the in vitro kinetic model

Article Snippet: In the third set of experiments, S. pneumoniae ATCC 6306, S. pneumoniae 2151, S. pyogenes 138, S. pyogenes 197, H. influenzae CCUG 23969, and H. influenzae NTCC 8468 at three different inocula (approximately 10 4 , 10 6 , and 10 8 CFU/ml) were exposed to telithromycin at a concentration of four times the MIC for each strain.

Techniques: In Vitro

Journal:

Article Title: Pharmacodynamics of Telithromycin In Vitro against Respiratory Tract Pathogens

doi: 10.1128/AAC.45.1.23-29.2001

Figure Lengend Snippet: Killing curves for telithromycin in the in vitro kinetic model. The half-life was 12 h. □, S. pneumoniae ATCC 6306 (Cmax = 0.008 mg/liter); ■, S. pneumoniae 2151 (Cmax = 0.032 mg/liter); ▵, S. pyogenes 197 (Cmax = 0.6 mg/liter); ▾, S. pyogenes 138 (Cmax = 0.6 mg/liter). Controls were S. pneumoniae ATCC 6306 (private-char pc1), S. pneumoniae R-2151 (▹), S. pyogenes 197 (×), and S. pyogenes 138 (✠).

Article Snippet: In the third set of experiments, S. pneumoniae ATCC 6306, S. pneumoniae 2151, S. pyogenes 138, S. pyogenes 197, H. influenzae CCUG 23969, and H. influenzae NTCC 8468 at three different inocula (approximately 10 4 , 10 6 , and 10 8 CFU/ml) were exposed to telithromycin at a concentration of four times the MIC for each strain.

Techniques: In Vitro